ID: 1031 Synthesis of Polymeric Nanoparticles of α-mangostin and its Cytotoxicity to Human Cancer Cell Lines
DOI:
https://doi.org/10.15419/bmrat.v4iS.307Keywords:
α-Mangostin, ß-cyclodextrin, Biology, cytotoxicity, cancer cellsAbstract
α-Mangostin (AMG) extracted from Garcinia mangostana L., has potent anti-cancer properties, however its clinical application is limited due to poor aqueous-solubility. Here, we successfully synthesised and characterised water-soluble ß-cyclodextrin-coated AMG 30-50 nm-size nanoparticles (NMG). Similar cytotoxic activities against LU-1 (human lung adenocarcinoma) and HL-60 (human promyelocytic leukemia) cancer cells of water-soluble NMG and organic-solvent soluble AMG were found with IC50 of 8.86 and 9.86 µg/mL, respectively. The data demonstrates that the nanoparticles improve bioavailability while maintain anti-cancer activity of AMG.
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Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
