Potential role of Factor V Leiden mutation in adverse pregnancy outcomes: An updated systematic review
DOI:
https://doi.org/10.15419/bmrat.v4i12.389Keywords:
Factor V Leiden, Mutation, Pregnancy outcomes, MedicineAbstract
Background: Thrombophilia is an inherited or acquired predisposition for development of thrombosis. One of the common thrombophilia polymorphisms is Factor V Leiden (FVL) mutation, which may contribute to negative pregnancy outcomes. This systematic review study seeks to describe the potential effects of factor V Leiden mutation on adverse pregnancy outcomes.
Methods: Pubmed, Embase, ISI Web of Sciences, Scopus, ScienceDirect, Proquest and Google Scholar, for articles published during 1996-2017. Articles were evaluated by the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for standard reporting. As well, the quality of studies was assessed by the Newcastle-Ottawa Scale (NOS).
Results: A total of 14 studies were eligible based on the inclusion criteria. The papers were scored by the STROBE checklist. The range of STROBE score was 15-20. Only 37.5% of the studies confirmed the relationship between fetal loss and FVL. The effect of FVL mutation on spontaneous abortions and In Vitro Fertilization (IVF) failures was demonstrated in all the studies. In the reviewed studies, there was no observed relationship between FVL mutation with intrauterine growth restriction (IUGR), preeclampsia, placental abruption or small for gestational age (SGA).
Conclusion: The reviewed studies showed an unclear association between FVL mutation and stillbirth, IUGR, preeclampsia, or placental abruption. The exact effects of hereditary thrombophilia on pregnancy outcome is also still controversial. However, FVL mutation appeared to have an effect on spontaneous abortions and IVF failures. Therefore, screening patients for thrombophilic polymorphisms might be helpful.
References
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</ol>
<li class="show">Abdi, F., & Roozbeh, N. (2016). The effects of Humulus Lupulus L.) Hops) on Menopausal Vasomotor Symptoms: A Systematic Review and Meta-analysis. Majallah-i Zanan, Mamai va Nazai-i Iran, 19, 9–17.</li>
<li class="show">Al Husseini, N. F., Rezk, A. Y., Odah, M. M., El Rahman, S. M., & Ali, A. I. (2011). Thrombophilic Genes Mutations in Women with Repeated In-Vitro Fertilization Failure. American Medical Journal, 2(1), 7–12. <a href="https://doi.org/10.3844/amjsp.2011.7.12">https://doi.org/10.3844/amjsp.2011.7.12</a></li>
<li class="show">Ardestani, M. T., Nodushan, H. H., Aflatoonian, A., Ghasemi, N., & Sheikhha, M. H. (2013). Case control study of the factor V Leiden and factor II G20210A mutation frequency in women with recurrent pregnancy loss. Iranian Journal of Reproductive Medicine, 11, 61.</li>
<li class="show">Ayadurai, T., Muniandy, S., & Omar, S. Z. (2009). Thrombophilia investigation in Malaysian women with recurrent pregnancy loss. Journal of Obstetrics and Gynaecology Research, 35(6), 1061–1068. <a href="https://doi.org/10.1111/j.1447-0756.2009.01067.x">https://doi.org/10.1111/j.1447-0756.2009.01067.x</a></li>
<li class="show">Azem, F., Many, A., Yovel, I., Amit, A., Lessing, J. B., & Kupferminc, M. J. (2004). Increased rates of thrombophilia in women with repeated IVF failures. Human Reproduction (Oxford, England), 19(2), 368–370. <a href="https://doi.org/10.1093/humrep/deh069">https://doi.org/10.1093/humrep/deh069</a></li>
<li class="show">Cardona, H., Castañeda, S. A., Cardona Maya, W., Alvarez, L., Gómez, J., Gómez, J., . . . Cadavid, Á. P. (2012). Lack of association between recurrent pregnancy loss and inherited thrombophilia in a group of Colombian patients. Thrombosis, •••, 2012.</li>
<li class="show">Carrington, B., Sacks, G., & Regan, L. (2005). Recurrent miscarriage: Pathophysiology and outcome. Current Opinion in Obstetrics & Gynecology, 17(6), 591–597. <a href="https://doi.org/10.1097/01.gco.0000194112.86051.26">https://doi.org/10.1097/01.gco.0000194112.86051.26</a></li>
<li class="show">Colman, R. W. (2006). Are hemostasis and thrombosis two sides of the same coin? The Journal of Experimental Medicine, 203(3), 493–495. <a href="https://doi.org/10.1084/jem.20060217">https://doi.org/10.1084/jem.20060217</a></li>
<li class="show">Daniela, L., De Lisa, E., Dellepiane, M., Storch, E., Attarian, D., Ferrari, A., . . . Motta, N. (2004). Trombofilia y pérdida recurrente de embarazo. La Revista Medica del Uruguay, 20, 106–113.</li>
<li class="show">De Stefano, V., & Leone, G. (1995). Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia. Haematologica, 80, 344–356.</li>
<li class="show">Dilley, A., Benito, C., Hooper, W., Austin, H., Miller, C., El-Jamil, M., . . . Patterson-Barnett, A. (2002). Mutations in the factor V, prothrombin and MTHFR genes are not risk factors for recurrent fetal loss. The Journal of Maternal-Fetal & Neonatal Medicine, 11(3), 176–182. <a href="https://doi.org/10.1080/jmf.11.3.176.182">https://doi.org/10.1080/jmf.11.3.176.182</a></li>
<li class="show">Dizon-Townson, D., Miller, C., Sibai, B., Spong, C. Y., Thom, E., Wendel, G., Jr., . . . Moawad, A. (2005). The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstetrics and Gynecology, 106(3), 517–524. <a href="https://doi.org/10.1097/01.AOG.0000173986.32528.ca">https://doi.org/10.1097/01.AOG.0000173986.32528.ca</a></li>
<li class="show">Doyle, N. M., & Monga, M. (2004). Thromboembolic disease in pregnancy. Obstetrics and Gynecology Clinics of North America, 31(2), 319–344. <a href="https://doi.org/10.1016/j.ogc.2004.03.008">https://doi.org/10.1016/j.ogc.2004.03.008</a></li>
<li class="show">Foka, Z., Lambropoulos, A., Saravelos, H., Karas, G., Karavida, A., Agorastos, T., . . . Kotsis, A. (2000). Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Human Reproduction (Oxford, England), 15(2), 458–462. <a href="https://doi.org/10.1093/humrep/15.2.458">https://doi.org/10.1093/humrep/15.2.458</a></li>
<li class="show">Gawish, G. E. (2011). Molecular characterization of factor V leiden G1691A and prothrombin G20210A mutations in Saudi newborns with stroke. Biochemical Genetics, 49(9-10), 601–610. <a href="https://doi.org/10.1007/s10528-011-9435-7">https://doi.org/10.1007/s10528-011-9435-7</a></li>
<li class="show">Goodman, C. S., Coulam, C. B., Jeyendran, R. S., Acosta, V. A., & Roussev, R. (2006). Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss? American Journal of Reproductive Immunology, 56(4), 230–236. <a href="https://doi.org/10.1111/j.1600-0897.2006.00419.x">https://doi.org/10.1111/j.1600-0897.2006.00419.x</a></li>
<li class="show">Göpel, W., Ludwig, M., Junge, A. K., Kohlmann, T., Diedrich, K., & Möller, J. (2001). Selection pressure for the factor-V-Leiden mutation and embryo implantation. Lancet, 358(9289), 1238–1239. <a href="https://doi.org/10.1016/S0140-6736(01)06354-1">https://doi.org/10.1016/S0140-6736(01)06354-1</a></li>
<li class="show">Grandone, E., Colaizzo, D., Bue, A. L., Checola, M. G., Cittadini, E., & Margaglione, M. (2001). Inherited thrombophilia and in vitro fertilization implantation failure. Fertility and Sterility, 76(1), 201–202. <a href="https://doi.org/10.1016/S0015-0282(01)01832-5">https://doi.org/10.1016/S0015-0282(01)01832-5</a></li>
<li class="show">Idali, F., Zareii, S., Mohammad‐Zadeh, A., Reihany‐Sabet, F., Akbarzadeh‐Pasha, Z., Khorram‐Khorshid, H. R., . . . Jeddi‐Tehrani, M. (2012). Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in Iranian women with polycystic ovary syndrome. American Journal of Reproductive Immunology, 68(5), 400–407. <a href="https://doi.org/10.1111/aji.12002">https://doi.org/10.1111/aji.12002</a></li>
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2017-12-18
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Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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Potential role of Factor V Leiden mutation in adverse pregnancy outcomes: An updated systematic review. (2017). Biomedical Research and Therapy, 4(12), 1832-1846. https://doi.org/10.15419/bmrat.v4i12.389
