Significance of Sialoglycans in SARS-CoV2 Infection

Authors

  • Saravanakarthikeyan Balasubramanian Conservative Dentistry and Endodontics, SRM Dental College, Ramapuram, SRM Institute of Science and Technology, Chennai- 600 089, Tamil Nadu, India https://orcid.org/0000-0003-1850-3581
  • Divya Vinayachandran Oral Medicine and Radiology, SRM Kattankulathur Dental College and Hospitals, SRM Institute of Science and Technology, Chennai- 603 203, Tamil Nadu, India https://orcid.org/0000-0001-7042-6435

DOI:

https://doi.org/10.15419/bmrat.v8i10.696

Keywords:

Coronavirus, N-acetylneuraminic acid, salivary diagnostics, sialic acid, targeted drug therapy

Abstract

The second wave of coronavirus disease 19 (COVID-19) has hit India badly with a rapid surge of cases. One of the greatest challenges in managing infections from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the incomplete knowledge regarding the disease course, hypersensitivity, and relative resistance in a number of individuals. Recently, it has been reported that besides the Angiotensin-converting enzyme 2 (ACE2), certain sialic acids present on the cell surface may also function as potential receptors for binding the spike protein of SARS-CoV-2. In this brief commentary we briefly discuss the role of sialic acids in SARS-CoV-2 infection and suggest more research investigations pertaining to this arena. This may pave the way for breakthrough solutions to combat the current pandemic more effectively by developing specific drug-targeted therapies.

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Published

2021-10-09

Issue

Section

Commentary

How to Cite

Significance of Sialoglycans in SARS-CoV2 Infection. (2021). Biomedical Research and Therapy, 8(10), 4612-4613. https://doi.org/10.15419/bmrat.v8i10.696

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