Neutrophil-to-lymphocyte ratio as a promising biomarker for the diagnosis of psoriasis in Pakistan

Authors

  • Benish Nawaz Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan
  • Muhammad Babar Khawar Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan https://orcid.org/0000-0002-1812-0591
  • Ali Afzal Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences & Technology, University of Central Punjab, Lahore, Pakistan https://orcid.org/0000-0003-3679-1257
  • Suneela Aman University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
  • Syeda Eisha Hamid Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences & Technology, University of Central Punjab, Lahore, Pakistan
  • Muddasir Hassan Abbasi Department of Zoology, University of Okara, Punjab, Pakistan https://orcid.org/0000-0001-7856-7013
  • Nadeem Sheikh Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Lahore, Pakistan https://orcid.org/0000-0001-9503-9538
  • Syed Shakeel Shah Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan
  • Mussarat Rafiq Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Lahore, Pakistan https://orcid.org/0000-0002-0300-5339
  • Fareeha Azam Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Lahore, Pakistan https://orcid.org/0000-0002-0489-0325
  • Rabia Mehmood Cell & Molecular Biology Lab, Institute of Zoology, University of the Punjab, Lahore, Pakistan https://orcid.org/0000-0002-9356-2787

DOI:

https://doi.org/10.15419/bmrat.v9i9.768

Keywords:

Biomarker, Hematology, neutrophils to lymphocyte ratio, Pakistan, Psoriasis

Abstract

Background: Psoriasis is a skin inflammation characterized by papules and plaques on the skin surface. Almost 125 million people are affected by psoriasis worldwide. This study aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) can be used as a biomarker for the diagnosis of psoriasis.

Methods: Blood samples of patients with psoriasis and healthy controls were collected for complete blood count testing. A t-test was applied to estimate the difference in the hematological parameters between the two groups.

Results: The hemoglobin level (p < 0.0001), hematocrit level (p < 0.0001), red blood cell count (p < 0.0001), mean corpuscular volume (p = 0.0002), platelet count (p = 0.0039), white blood cell count (p = 0.0002), neutrophil count (p = 0.0001), monocyte count (p < 0.0001), and eosinophil count (p = 0.0467) significantly differed between the groups. Meanwhile, the mean corpuscular hemoglobin concentration (p = 0.3989) and lymphocyte count (p = 0.3842) did not. The patients with psoriasis had a higher neutrophil count and a lower lymphocyte count than the healthy controls. The NLR was significantly elevated in the patients with psoriasis.

Conclusion: The NLR is a potential biomarker for the diagnosis of psoriasis.

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Published

2022-09-30

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How to Cite

Neutrophil-to-lymphocyte ratio as a promising biomarker for the diagnosis of psoriasis in Pakistan. (2022). Biomedical Research and Therapy, 9(9), 5306-5312. https://doi.org/10.15419/bmrat.v9i9.768

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