Neutrophil-to-lymphocyte ratio as a promising biomarker for the diagnosis of psoriasis in Pakistan
DOI:
https://doi.org/10.15419/bmrat.v9i9.768Keywords:
Biomarker, Hematology, neutrophils to lymphocyte ratio, Pakistan, PsoriasisAbstract
Background: Psoriasis is a skin inflammation characterized by papules and plaques on the skin surface. Almost 125 million people are affected by psoriasis worldwide. This study aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) can be used as a biomarker for the diagnosis of psoriasis.
Methods: Blood samples of patients with psoriasis and healthy controls were collected for complete blood count testing. A t-test was applied to estimate the difference in the hematological parameters between the two groups.
Results: The hemoglobin level (p < 0.0001), hematocrit level (p < 0.0001), red blood cell count (p < 0.0001), mean corpuscular volume (p = 0.0002), platelet count (p = 0.0039), white blood cell count (p = 0.0002), neutrophil count (p = 0.0001), monocyte count (p < 0.0001), and eosinophil count (p = 0.0467) significantly differed between the groups. Meanwhile, the mean corpuscular hemoglobin concentration (p = 0.3989) and lymphocyte count (p = 0.3842) did not. The patients with psoriasis had a higher neutrophil count and a lower lymphocyte count than the healthy controls. The NLR was significantly elevated in the patients with psoriasis.
Conclusion: The NLR is a potential biomarker for the diagnosis of psoriasis.
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Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
