Authors
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Victoria A. Shestakova
National Medical Research Radiological Center; Koroleva st. 4, Obninsk, 249036, Kaluga region, Russia; Obninsk Institute for Nuclear Power Engineering of the National Research Nuclear University MEPhI; Studgorodok st., 1, Obninsk, 249040, Kaluga region, Russia
https://orcid.org/0000-0002-4129-8750
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Ilya D. Klabukov
National Medical Research Radiological Center; Koroleva st. 4, Obninsk, 249036, Kaluga region, Russia; Obninsk Institute for Nuclear Power Engineering of the National Research Nuclear University MEPhI; Studgorodok st., 1, Obninsk, 249040, Kaluga region, Russia; Peoples’ Friendship University of Russia (RUDN University); Ul. Miklukho-Maklaya 16/10, Moscow, 117437, Russia
https://orcid.org/0000-0002-2888-7999
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Denis S. Baranovskii
National Medical Research Radiological Center; Koroleva st. 4, Obninsk, 249036, Kaluga region, Russia; Peoples’ Friendship University of Russia (RUDN University); Ul. Miklukho-Maklaya 16/10, Moscow, 117437, Russia
https://orcid.org/0000-0002-6154-9959
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Petr V. Shegay
National Medical Research Radiological Center; Koroleva st. 4, Obninsk, 249036, Kaluga region, Russia
https://orcid.org/0000-0001-8901-4596
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Andrey D. Kaprin
National Medical Research Radiological Center; Koroleva st. 4, Obninsk, 249036, Kaluga region, Russia; Peoples’ Friendship University of Russia (RUDN University); Ul. Miklukho-Maklaya 16/10, Moscow, 117437, Russia
https://orcid.org/0000-0001-8784-8415
Keywords:
cell therapy, immunity, immunological response, regenerative medicine, tissue engineering
Abstract
The number of articles on tissue engineering and regenerative medicine has increased dramatically in the last decade; however, the number of clinically implemented techniques remains small. Possible reasons include insufficient investigation of immune reactions on implanted tissue-engineered grafts and cells or a lack of consensus regarding which immunological tests must be performed to evaluate immunological responses. To provide an example of insufficiency in the assessment of immunological reactions, we analyzed three papers published between 2020 and 2021 and discussed the possibility of creating a standardized assay palette for the assessment of immunological responses in different types of implants.
License
Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
How to Cite
Assessment of Immunological Responses - A Novel Challenge in Tissue Engineering and Regenerative Medicine. (2022).
Biomedical Research and Therapy,
9(11), 5384-5386.
https://doi.org/10.15419/bmrat.v9i11.776
