Authors
-
Nguyen Van Hung
Department of Pathology, Phenikaa University, Vietnam, Nguyen Trac Street, Ha Dong District, Ha Noi City, Viet Nam; Department of Pathology, Hanoi Medical University, Vietnam, 1 Ton That Tung Street, Dong Da District, Ha Noi City, Viet Nam
-
Phạm Duy Dat
Department of Pathology, Saint Paul Hospital, 12 Chu Van An Street, Ba Dinh District, Ha Noi City, Viet Nam
-
Nguyen Tuan Thanh
Pathological and Cytopathological Center, Bach Mai Hospital, 78, Giai Phong Street, Dong Da District, Ha Noi City, Viet Nam
-
Tran Ngoc Minh
Department of Pathology, Hanoi Medical University, Vietnam, 1 Ton That Tung Street, Dong Da District, Ha Noi City, Viet Nam; Department of Pathology, Hospital of Hanoi Medical University, Viet Nam, 1, Ton That Tung Street, Dong Da District, Ha Noi City, Viet Nam
-
Nguyen Thuy Huong
Department of Pathology, Phenikaa University, Vietnam, Nguyen Trac Street, Ha Dong District, Ha Noi City, Viet Nam
-
Dao Thi Luan
Department of Pathology, Hanoi Medical University, Vietnam, 1 Ton That Tung Street, Dong Da District, Ha Noi City, Viet Nam; Department of Pathology, Hospital of Hanoi Medical University, Viet Nam, 1, Ton That Tung Street, Dong Da District, Ha Noi City, Viet Nam
-
Hoang Thi Ngoc Mai
Department of Pathology, Hospital of Hanoi Medical University, Viet Nam, 1, Ton That Tung Street, Dong Da District, Ha Noi City, Viet Nam
Keywords:
Multiple primary cancer, Histological heterogeneity, Primary and metastatic tumors, Primary sites of squamous cell carcinoma, Phenotypic plasticity
Abstract
The simultaneous (synchronous) detection of 3 primary tumors is rare in clinical practice. Recognizing and differentiating metastatic malignancies have always been challenging for clinicians and pathologists; however, treatment outcomes and prognoses highly depend on this recognition. Here, we used immunostaining and a new approach that, to our knowledge, few people know about based on an understanding of exosomal microRNAs (miRNAs), phenotypic plasticity, and the tumor microenvironment to reach a final diagnosis of multiple primary neoplasms.
Author Biography
-
Nguyen Van Hung, Department of Pathology, Phenikaa University, Vietnam, Nguyen Trac Street, Ha Dong District, Ha Noi City, Viet Nam; Department of Pathology, Hanoi Medical University, Vietnam, 1 Ton That Tung Street, Dong Da District, Ha Noi City, Viet Nam
License
Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
How to Cite
Simultaneous detection of 3 cancer foci with histological heterogeneity at 3 different anatomical sites: is it a consequence of the phenotypic plasticity of tumor cells?. (2022).
Biomedical Research and Therapy,
9(11), 5387-5393.
https://doi.org/10.15419/bmrat.v9i11.777
