Genes involved in premature aging and their association with age-related diseases: A mini review

Abstract

Aging is an irreversible biological process observed in living organisms, with each cell demonstrating this mechanism. Age-related decline in cellular integrity due to various endogenous and exogenous factors and mechanisms contributes to several diseases based on the site or location of the decline. Cardiovascular diseases, diabetes, cancer, osteoarthritis, and osteoporosis are some examples of age-related diseases. Reports suggest several premature aging genes contribute to the genetic, pathological, and physiological variations of an organism that is similar to the aging organism and might explain the genes associated with aging. We used the DisGeNET web tool to retrieve genes associated with premature aging. We used the Cytoscape software and STRING online tool for identifying protein-protein networks. We retrieved 136 genes associated with premature aging and compared their association with age-related diseases. Many of these premature agingassociated genes were associated with cardiovascular disease (56), diabetes type II (71), Parkinson's disease (54), Alzheimer's disease (86), prostate cancer progression (23), osteoarthritis (15), osteoporosis (53), age-related macular degeneration (35), cataracts (44), and sensorineural hearing loss (26). This article provides a brief review of some of the genes involved in premature aging.