First report of chronic portal vein thrombosis successfully managed with splenectomy and long-term direct oral anticoagulants

Authors

  • Tien Manh Huynh University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Sang Thanh Nguyen Nhan Dan Gia Dinh Hospital, Ho Chi Minh City, Viet Nam
  • Ngoc Thanh Lam University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • An Le Pham University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam
  • Si Van Nguyen University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam

DOI:

https://doi.org/10.15419/bmrat.v11i2.866

Keywords:

non-cirrhotic portal hypertension, portal vein thrombosis, splenectomy, direct oral anticoagulants

Abstract

We report a rare case of portal vein thrombosis (PVT) secondary to idiopathic hypercoagulability leading to non-cirrhotic portal hypertension and cavernous transformation. The patient had a history of acute PVT and superior mesenteric vein thrombosis, which was initially managed successfully with anticoagulation therapy. However, the discontinuation of treatment precipitated a transition to chronic PVT and subsequent cavernous transformation. This condition manifested clinically as esophageal and gastric varices, posing a significant bleeding risk. Attempts to mitigate portal hypertension through medical management and endoscopic interventions had limited success. The anatomical complexities presented an insurmountable challenge to transjugular intrahepatic portosystemic shunt (TIPS) placement, and thus alternative treatment strategies were considered. A splenectomy markedly improved the patient's condition. Over a 2-year follow-up period, with the aid of direct oral anticoagulants (DOACs), the patient remained stable; further endoscopic procedures were not required, and the patient did not experience a recurrence of thromboembolic or hemorrhagic events. This case underscores the complexity of PVT management and highlights the need for individualized treatment approaches in the face of anatomical and therapeutic challenges.

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Published

2024-02-29

Issue

Section

Case report

How to Cite

First report of chronic portal vein thrombosis successfully managed with splenectomy and long-term direct oral anticoagulants. (2024). Biomedical Research and Therapy, 11(2), 6203-6208. https://doi.org/10.15419/bmrat.v11i2.866

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