Authors
-
Razan Hayati Zulkeflee
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0003-2760-0703
-
Mohd Nazri Hassan
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0003-4975-2038
-
Zefarina Zulkafli
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0003-2029-2234
-
Noor Haslina Mohd Noor
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
-
Azlan Husin
Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Department of Internal Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0003-0899-0443
-
Abu Dzarr Abdullah
Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Department of Internal Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
-
Shafini Mohamed Yusoff
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0001-8950-5715
-
Marini Ramli
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0002-9104-7511
-
Rosnah Bahar
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0003-4276-7288
-
Wan Suriana Wan Abd Rahman
Department of Internal Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
-
Norzaliana Zawawi
Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
https://orcid.org/0000-0003-3640-0383
Keywords:
Chronic myeloid leukaemia, Myeloid sarcoma, Osteolytic lesion
Abstract
Background: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that typically occurs in the fifth and sixth decades of life with presentations usually confined to hematopoietic tissues—primarily blood, bone marrow, and spleen. However, primary presentation of CML as extramedullary involvement (osteolytic lesion) is extremely rare, occurring in less than 1% of cases.
Case Presentation: Here, we present a case of a 25-year-old male with chronic myeloid leukemia (CML), characterized by an atypical presentation of a femur fracture accompanied by an osteolytic lesion. The peripheral blood findings displayed typical features of CML, including leukocytosis with a full spectrum of myeloid maturation stages, basophilia, and occasional blasts. The diagnosis of CML in the blastic phase was confirmed by the presence of the Philadelphia chromosome and the BCR-ABL1 fusion gene (b2a2), as well as features of myeloid sarcoma in the tissue biopsy.
Conclusion: Given the aggressive nature of granulocytic sarcoma and its impact on prognosis, early recognition and intervention are essential to mitigate complications and improve patient outcomes.
Author Biography
-
Mohd Nazri Hassan, Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia; Hospital USM, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia
License
Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
How to Cite
An Uncommon Presentation of Chronic Myeloid Leukemia: Osteolytic Bone Lesion as the Initial Manifestation. (2024).
Biomedical Research and Therapy,
11(3), 6276-6281.
https://doi.org/10.15419/bmrat.v11i3.873
