Association between Ag-NOR dots and immunohistochemical markers in different grades of breast ductal carcinoma
DOI:
https://doi.org/10.15419/bmrat.v11i5.889Keywords:
AgNOR, ER, Progesterone receptors, immunohistochemical expression, H and EAbstract
Background: Breast cancer is recognized as a significant health issue in developed countries.
Methods: This study aimed to correlate the presence of Ag-NOR (argentophilic nucleolar organizer region) dots with immunohistochemical markers across various grades of breast ductal carcinoma. A total of 100 samples were divided into a test group and a control group, with the former comprising blocks of breast adenocarcinoma and the latter involving blocks of breast fibroadenoma. Each sample was sectioned twice; the first section was stained with Hematoxylin and Eosin (H&E), and the second utilized the Ag-NOR staining technique. The mean Ag-NOR (mAg-NOR) count and the proliferative Ag-NOR (pAg-NOR) count were calculated. Subsequent to microscopic examination of the sections, the laboratory findings and patient demographic data were analyzed.
Results: The majority of ductal carcinoma cases were classified as grade 2. The number of Ag-NOR dots was significantly greater in ductal carcinoma cases than in benign lesions. Furthermore, an increase in the number of Ag-NOR dots was observed with advancing tumor grade.
Conclusions: A strong correlation was identified between the count of Ag-NOR dots and the expression of immunohistochemical markers within different grades of breast ductal carcinoma.
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Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
