Acquired Platelet Dysfunction with Eosinophilia: A Case Series

Abstract

Background: Acquired platelet dysfunction with eosinophilia (APDE) is characterized by a temporary impairment in platelet function accompanied by significant eosinophilia. This condition, also known as "non-thrombocytopenic purpura with eosinophilia," primarily affects children in the South-East Asian region, presenting as a bleeding disorder.

Case Presentation: In this case series, we report on three patients who were admitted to our hospital displaying skin bruising, despite being previously healthy, with no history of drug use or recent travel. These patients exhibited classic signs of APDE, and interestingly, some showed spontaneous recovery without the need for medical intervention. Diagnostic evaluations revealed an increased eosinophil count, whereas the basic hemostatic parameters and platelet counts remained within normal limits. However, platelet aggregation studies indicated abnormalities.

Conclusion: It is crucial to identify this benign disorder promptly, as providing reassurance to patients and their families plays a critical role in the management of APDE.