ID:2040 Antileukemic and antiplatelet activities of indirubin-3'-oxime, an active ingredient semi-synthesized from indirubin-rich powder of medicinal plant Strobilanthes cusia (Nees.) O. Kuntze (Acanthaceae)
DOI:
https://doi.org/10.15419/bmrat.v4iS.278Keywords:
Biology, Indirubin-3'-oxime, Strobilanthes cussiaAbstract
Indirubin-3’-oxime (IOX) is an active ingredient semi-synthesized from indirubin-rich powder produced from medicinal plant Strobilanthes cusia (Nees.) O. Kuntze (Acanthaceae). IOX exhibits antileukemic and antiplatelet activities. IOX inhibited the growth of human promyelocytic leukemia HL-60 cells with a GI50 value of 36.6 µM. Oral administration (20 mg kg-1day-1) of IOX for 3 days significantly prolonged occlusion time in a rat carotid artery injury model, and ADP- and collagen-induced platelet aggregation, comparable with aspirin. IOX markedly reduced collagen-induced phosphorylation of extracellular signal-regulated kinase ERK1/2 and p47, resulting in the blockade of cyclooxygenase (COX)-mediated AA metabolite production in AA-treated platelets. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic and antiplatelet drug
References
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Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
