Art of using maintenance therapy in a patient with metastatic colon cancer harboring RAS-wt/BRAF V600E

Authors

  • Mehrdad Payandeh Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Afshin Karami Department of Hematology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Noorodin Karami Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI:

https://doi.org/10.15419/bmrat.v9i9.767

Keywords:

Colon cancer, FOLFIRINOX, BRAF V600E, Vemurafenib

Abstract

Background: Colorectal cancer is one of the most common malignancies with a high rate of liver metastasis, and various gene mutations have been proven to be involved in its pathogenesis. One of them is BRAF gene mutations, the most frequent of which—V600E—has a poor prognosis in patients with colon cancer.

Case presentation: By applying the FOLFIRINOX regimen and a specific maintenance strategy containing vemurafenib, we achieved disappearance of metastatic lesions, no recurrence, and good stability in a Kurdish patient with metastatic colon cancer harboring RASwt/ BRAF V600E.

Conclusion: Our therapeutic strategy allows the selection of the most appropriate treatment approach for patients.

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Published

2022-09-30

Issue

Vol. 9 No. 9 (2022)

Section

Case report

License

Copyright The Author(s) 2017. This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

How to Cite

Art of using maintenance therapy in a patient with metastatic colon cancer harboring RAS-wt/BRAF V600E. (2022). Biomedical Research and Therapy, 9(9), 5301-5305. https://doi.org/10.15419/bmrat.v9i9.767

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