Cyclosporine-A induced nephrotoxicity in male and female rats: Is zinc a suitable protective supplement?

Authors

  • Samira Choopani Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  • Sayyedehnikta Kasaei Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  • Ardeshir Talebi Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  • Mojgan Mortazavi Isfahan Kidney diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  • Yousef Gheisari Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  • Mohammad Matinfar Isfahan Kidney diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  • Mehdi Nematbakhsh Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran

DOI:

https://doi.org/10.15419/bmrat.v5i12.507

Keywords:

Cyclosporine, Gender, Nephrotoxicity, Renal function, Zinc

Abstract

Background: Cyclosporine (CYC) is an immunosuppressant drug used widely in kidney transplant patient. The major side effect of CYC is nephrotoxicity. In this study, three different doses of CYC alone or accompanied with zinc (Zn) supplement were administrated in male and female rats to determine the kidney tissue damages and functions.

Methods: Male and female rats were treated with 10, 50 or 100 mg/kg/day of CYC alone or accompanied with 10 mg /kg/day of Zn sulfate for 10 days. The parameters related to renal function were determined and the kidney tissues were subjected to histological evaluation.

Results: All male and female animals were treated with high dose CYC (100 mg/kg/day) alone or accompanied with Zn supplement during the experiment. The data obtained for the serum levels of creatinine (Cr) and blood urea nitrogen/Cr ratio, clearance of Cr, kidney weight (KW), sodium (Na) filtration rate, Na excretion rate and Na excretion fraction (%) in surviving animals suggest a role of gender in the variation of these factors. The kidney tissue damage score (KTDS) was increased as the dosage of CYC was elevated, and the Zn supplement attenuated the KTDS in animals treated with low dose CYC (10 mg/kg/day).

Conclusion: The CYC-induced nephrotoxicity may be gender-related, and the 10 mg/kg dose of Zn sulphate as a supplement may possibly prevent the induced nephrotoxicity in males due to its antioxidant effects.

 

Published

2018-12-25

Issue

Section

Original Research

How to Cite

Cyclosporine-A induced nephrotoxicity in male and female rats: Is zinc a suitable protective supplement?. (2018). Biomedical Research and Therapy, 5(12), 2888-2897. https://doi.org/10.15419/bmrat.v5i12.507

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